Genetic epilepsy model derived from common inbred mouse strains.

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Genetic epilepsy model derived from common inbred mouse strains.

The recombinant inbred mouse strain, SWXL-4, exhibits tonic-clonic and generalized seizures similar to the commonest epilepsies in humans. In SWXL-4 animals, seizures are observed following routine handling at about 80 days of age and may be induced as early as 55 days by rhythmic gentle tossing. Seizures are accompanied by rapid, bilateral high frequency spike cortical discharges and followed ...

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With the completion of the mouse genome sequence, it is possible to define the amount, type, and organization of the genetic variation in this species. Recent reports have provided an overview of the structure of genetic variation among classical laboratory mice. On the other hand, little is known about the structure of genetic variation among wild-derived strains with the exception of the pres...

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ژورنال

عنوان ژورنال: Genetics

سال: 1994

ISSN: 1943-2631

DOI: 10.1093/genetics/138.2.481